The Northern Oesophago-Gastric Unit has been involved in research for 30 years. We have an interest in both clinical research and translational research (basic sciences), and usually have at least one research registrar undertaking an MD or PhD.  

Our current research registrars are Miss Pooja Prasad who is commencing a study on “rehabilitation” to see if we can accelerate improvements in quality of life after surgery, and Mr Ersong Shang who is carrying out translational research.

Papers from NOGU and collaborations, are regularly published in peer review journals and links to abstracts can be found here.  

2024

1. Novel Textbook Outcomes following emergency laparotomy: Delphi exercise. Beacon Collaborative. BJS Open
2. The Prognostic Impact of Minimally Invasive Esophagectomy on Survival after Esophagectomy following a Delayed Interval after Chemoradiotherapy; A Secondary Analysis of the DICE Study. Annals of Surgery
3. Surgical Techniques and Related Perioperative Outcomes After Robot-assisted Minimally Invasive Gastrectomy (RAMIG): Results From the Prospective Multicenter International Ugira Gastric Registry. Annals of Surgery
4. Recurrence and Survival After Minimally Invasive and Open Esophagectomy for Esophageal Cancer: A Post Hoc Analysis of the Ensure Study. Annals of Surgery
5. Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis. BJS Open
6. National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma. GUT
7. Long-term survival is not affected by severity of complications following esophagectomy. EJSO
8. The yield of diagnostic laparoscopy with peritoneal lavage in gastric adenocarcinoma: A retrospective cohort study. EJSO
9. An international Delphi consensus for surgical quality assessment of lymphadenectomy and anastomosis in minimally invasive total gastrectomy for gastric cancer. Surg Endosc

2023

1. Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial. Lancet Oncology
2. Clinical impact of routine response assessment after preoperative chemotherapy in patients with gastric cancer. British Journal of Surgery Open
3. Hybrid laparoscopic versus fully robot-assisted minimally invasive esophagectomy: an international propensity-score matched analysis of perioperative outcome Surgical Endoscopy
4. Appendicectomy remains treatment of choice for patients with acute appendicitis. British Medical Journal
5. Delayed Surgical Intervention After Chemoradiotherapy in Esophageal Cancer: (DICE) Study. Annals of Surgery
6. Neoadjuvant Chemoradiotherapy Versus Chemotherapy for the Treatment of Locally Advanced Esophageal Adenocarcinoma in the European Multicenter ENSURE Study. Annals of Surgery
7. Prognostic implications of the extent of downstaging after neoadjuvant therapy for oesophageal adenocarcinoma and oesophageal squamous cell carcinoma. British Journal of Surgery Open
8. Treatment of anastomotic leak after oesophagectomy for oesophageal cancer: large, collaborative, observational TENTACLE cohort study. British Journal of Surgery
9. Histological prognosticators in neoadjuvant naive oesophageal cancer patients. Langenbecks Archives of Surgery
10. Multicenter, Prospective Cohort Study of Oesophageal Injuries and Related Clinical Outcomes (MUSOIC study). Annals of Surgery
11. Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue. European Journal of Surgical Oncology
12. The Surgical Trainer. Journal of Surgical Education

2022

1. Investigating dysphagia in adults: symptoms and tests. British Medical Journal
2. Are intra-operative gastric drainage procedures necessary in esophagectomy: a systematic review and meta-analysis. Langenbecks Arch Surg
3. Current issues and future considerations for the wider implementation of robotic-assisted surgery: a qualitative study British Medical Journal Open
4. Exploring factors influencing uptake and adherence to a home-based prehabilitation physical activity and exercise intervention for patients undergoing chemotherapy before major surgery (ChemoFit): a qualitative study. British Medical Journal Open
5. A feasibility trial of prehabilitation before oesophagogastric cancer surgery using a multi-component home-based exercise programme: the ChemoFit study. Pilot and Feasibility Studies
6. Severity of oEsophageal Anastomotic Leak in patients after oesophagectomy: the SEAL score British Journal of Surgery
7. Survival benefit of adjuvant chemotherapy following neoadjuvant therapy and oesophagectomy in oesophageal adenocarcinoma. European Journal of Surgical Oncology
8. Incidence, Diagnosis and Management of Malabsorption Following Oesophagectomy: a Systematic Review. Journal of Gastrointestinal Surgery
9. The impact of age on long-term survival following gastrectomy for gastric cancer. Annals of the Royal College of Surgeons of England
10. Significance of neoadjuvant downstaging in gastric adenocarcinoma. Surgery
11. An International Multicenter Study Exploring Whether Surveillance After Esophageal Cancer Surgery Impacts Oncological and Quality of Life Outcomes Annals of Surgery
12. Robotic Techniques in Esophagogastric Cancer Surgery: An Assessment of Short- and Long-Term Clinical Outcomes. Annals of Surgical Oncology
13. Learning curves in minimally invasive esophagectomy: A systematic review and evaluation of benchmarking parameters. Surgery
14. ASO Author Reflections: Modern-Day Implementation of Robotic Esophagogastric Cancer Surgery. Annals of Surgical Oncology
15. Esophageal and gastric malignancies after bariatric surgery: a retrospective global study. Surgery for Obesity and Related Diseases
16. Online patient literature related to oesophageal surgery: the need for greater readability, accreditation and higher quality. Annals of the Royal College of Surgeons of England
17. A Bibliometric Analysis of Robotic Surgery From 2001 to 2021. World Journal of Surgery
18. Outcomes after totally minimally invasive versus hybrid and open Ivor Lewis oesophagectomy: results from the International Esodata Study Group. British Journal of Surgery
19. Risk Prediction Model of 90-Day Mortality After Esophagectomy for Cancer. JAMA Surgery
20. Anastomotic stricture after Ivor Lewis esophagectomy: An evaluation of incidence, risk factors, and treatment. Surgery
21. ASO Author Reflections: Challenges in the Management of Gastroesophageal Junctional Adenocarcinoma. Annals of Surgical Oncology

2021

1. Palliative gastrectomy for metastatic gastric adenocarcinoma: A national population-based cohort study. Surgery
2. FLOT-regimen Chemotherapy and Transthoracic en bloc Resection for Esophageal and Junctional Adenocarcinoma. Annals of Surgery
3. Prehabilitation, improving postoperative outcomes. Rozhl Chir
4. Multimodal analgesia with thoracic epidural after transthoracic oesophagectomy: Do we need more evidence? British Journal of Surgery
5. Comparison of the effects of FLOT and ECX chemotherapy for oesophagogastric adenocarcinoma on cardiopulmonary reserve. British Journal of Surgery
6. Esophagectomy or Total Gastrectomy for Siewert 2 Gastroesophageal Junction (GEJ) Adenocarcinoma? A Registry-Based Analyrysis. Annals of Surgical Oncology
7. ASO Visual Abstract: Esophagectomy or Total Gastrectomy for Siewert 2 Gastroesophageal Junction (GEJ) Adenocarcinoma? A Registry-Based Analysis. Annals of Surgical Oncology
8. Risk Prediction Model of 90-Day Mortality After Esophagectomy for Cancer. JAMA Surgery
9. Response to “Comment on: Impact of anastomotic leak on long-term survival in patients undergoing gastrectomy for gastric cancer” British Journal of Surgery
10. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. British Journal of Surgery
11. Does Cardiopulmonary Testing Help Predict Long-Term Survival After Esophagectomy? Annals of Surgical Oncology
12. ASO Visual Abstract: Does Cardiopulmonary Testing Help Predict Long-Term Survival After Esophagectomy? Annals of Surgical Oncology
13. ASO Author Reflection: Is There a Role for Cardiopulmonary Exercise Testing Before Esophagectomy? Annals of Surgical Oncology
14. Neoadjuvant chemoradiotherapy or chemotherapy alone for oesophageal cancer: population-based cohort study. British Journal of Surgery
15. Three decades of oesophagogastric care: now a curable disease British Journal of Surgery
16. Evolution of gastrectomy for cancer over 30-years: Changes in presentation, management, and outcomes Surgery
17. Impact of Smoking Status on Perioperative Morbidity, Mortality, and Long-Term Survival Following Transthoracic Esophagectomy for Esophageal Cancer Annals of Surgical Oncology
18. ASO Author Reflections: Smoking Status Impact on Perioperative Morbidity and Long-Term Survival of Patients Undergoing Esophagectomy for Cancer Annals of Surgical Oncology
19. Comparison of multimodal analgesia with thoracic epidural after transthoracic oesophagectomy British Journal of Surgery
20. Local Endoscopic Resection is Inferior to Gastrectomy for Early Clinical Stage T1a and T1b Gastric Adenocarcinoma: A Propensity-Matched Study. Annals of Surgical Oncology
21. ASO Author Reflections: Endoscopic Resection or Gastrectomy for Early Clinical Stage T1a or T1b Gastric Adenocarcinoma. Annals of Surgical Oncology
22. Comment on “Learning Curves of Ivor Lewis Totally Minimally Invasive Esophagectomy by Hospital and Surgeon Characteristics: A Retrospective Multinational Cohort Study”. Annals of Surgery

2020

2019

1. ASO Author Reflections: Lymphadenectomy in Esophagectomy: Why Bother? Annals of Surgical Oncology
2. Impact of Lymphadenectomy on Survival After Unimodality Transthoracic Esophagectomy for Adenocarcinoma of Esophagus. Annals of Surgical Oncology
3. Quality assurance of surgery in the randomized ST03 trial of perioperative chemotherapy in carcinoma of the stomach and gastro-oesophageal junction. British Journal of Surgery 
4. Impact of trainee involvement in esophagectomy on clinical outcomes: a narrative systematic review of the literature. Diseases of the Esophagus 
5. Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis. Thorax 
6. Cytokine Response in the Pleural Fluid and Blood in Minimally Invasive and Open Esophagectomy. World Journal of Surgery 
7. Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer. New England Journal of Surgery  
8. Comparison of totally laparoscopic total gastrectomy and laparoscopic assisted total gastrectomy: A systematic review and meta-analysis. International Journal of Surgery 
9. Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations. World Journal of Surgery  
10. An evaluation of the epidemiology, management and outcomes for perforated peptic ulcers across the North of England over 15 years: A retrospective cohort study. International Journal of Surgery 

Click on the images to read posters associated with the conference.

2018

1. Intra- and interobserver variability in skeletal muscle measurements using computed tomography images. European Journal of Radiology 
2. Asynchronous Unsupervised Video-Enhanced Feedback As Effective As Direct Expert Feedback in the Long-Term Retention of Practical Clinical Skills: Randomised Trial Comparing 2 Feedback Methods in a Cohort of Novice Medical Students. J Surgical Education 
3. Surgical Management of Gastric Gastrointestinal Stromal Tumours: Comparison of Outcomes for Local and Radical Resection. Gastroenterology Research and Practice 
4. Cardiopulmonary fitness before and after neoadjuvant chemotherapy in patients with oesophagogastric cancer. British Journal of Surgery  
5. Multimodal analgesia using intrathecal diamorphine, and paravertebral and rectus sheath catheters are as effective as thoracic epidural for analgesia post-open two-phase esophagectomy within an enhanced recovery program. Diseases of the Esophagus 
6. A tale of three stents: aortic stenting prior to oesophagectomy after oesophageal stents. Annals of the Royal College of Surgeons 
7. Trainee Involvement in Ivor Lewis Esophagectomy Does Not Negatively Impact Outcomes. Annals of Surgery 
8. Influence of national centralization of oesophagogastric cancer on management and clinical outcome from emergency upper gastrointestinal conditions. British Journal of Surgery 
9. The influence of procedural volume and proficiency gain on mortality from upper GI endoscopic mucosal resection. Gut 

2017

1. Pre-operative variables including fitness associated with complications after oesophagectomy. Anaesthesia 
2. Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK MRC OE05): an open-label, randomised phase 3 trial. Lancet Oncology 
3. Letter in response to Singh et al: A Randomized Controlled Study to Evaluate the Role of Video-based Coaching in Training Laparoscopic Skills. Annals of Surgery 
4. ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS). BMC Cancer 
5. Clinical outcomes and benefits for staging of surgical lymph node mapping after esophagectomy. Diseases of the Esophagus 
6. Impact of Extent of Lymphadenectomy on Survival, Post Neoadjuvant Chemotherapy and Transthoracic Esophagectomy. Annals of Surgery  
7. Cancer of the esophagus and esophagogastric junction: an 8^th edition staging primer. Journal of Thoracic Diseases 
8. Systemic inflammatory markers and outcome in patients with locally advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction. British Journal of Surgery 
9. Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial. Lancet Oncology 
10. Individualised Expert Feedback is Not Essential for Improving Basic Clinical Skills Performance in Novice Learners: A Randomized Trial. Journal of Surgical Education 

2016

1. Columnar Metaplasia in the Esophageal Remnant After Esophagectomy: A Common Occurrence and a Valuable Insight Into the Development of Barrett Esophagus. Annals of Surgery 
2. Surgical Proficiency in the Era of Centralization. Journal of Clinical Oncology 
3. Prognostic Significance of the Location of Lymph Node Metastases in Patients With Adenocarcinoma of the Distal Esophagus or Gastroesophageal Junction. Annals of Surgery 
4. Prognostic impact of extracapsular lymph node involvement after neoadjuvant therapy and oesophagectomy. British Journal of Surgery 
5. Recommendations for pathologic staging (pTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Diseases of the Esophagus 
6. Recommendations for clinical staging (cTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Diseases of the Esophagus 
7. Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Diseases of the Esophagus 
8. Worldwide Esophageal Cancer Collaboration: clinical staging data. Diseases of the Esophagus 
9. Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data. Diseases of the Esophagus 
10. Worldwide Esophageal Cancer Collaboration: pathologic staging data. Diseases of the Esophagus 
11. The impact of neoadjuvant chemotherapy on cardiopulmonary physical fitness in gastro-oesophageal adenocarcinoma. Annals of the Royal College of Surgeons of England 
12. Management and outcomes of anastomotic leaks after oesophagectomy. British Journal of Surgery  
13. What surgeons tell patients and what patients want to know before major cancer surgery: a qualitative study. BMC Cancer 
14. Fitness after chemotherapy. British Journal of Anaesthesia