The Northern Oesophago-Gastric Unit has been involved in research for 30 years. We have an interest in both clinical research and translational research (basic sciences), and usually have at least one research registrar undertaking an MD or PhD.  

Our current research registrar is Jakub Chmelo, who is undertaking a study to look at the feasibility of “prehabilitation”.  We know that patients will do better at the time of surgery if their fitness is good, and the aim of his study is to try and help patients maintain fitness whilst they receive chemotherapy prior to surgery.  

Papers from NOGU and collaborations, are regularly published in peer review journals and links to abstracts can be found here.  


  1. The Impact of Age on Patients Undergoing Transthoracic Esophagectomy for Cancer Diseases of the Esophagus
  2. Is Local Endoscopic Resection a Viable Therapeutic Option for Early Clinical Stage T1a and T1b Esophageal Adenocarcinoma?: A Propensity-Matched Analysis Annals of Surgery
  3. Impact of Anastomotic Leak on Long-Term Survival in Patients Undergoing Gastrectomy for Gastric Cancer British Journal of Surgery
  4. The Influence of the SARS-CoV-2 Pandemic on Esophagogastric Cancer Services: An International Survey of Esophagogastric Surgeon. Diseases of the Esophagus
  5. Signet Ring Gastric and Esophageal Adenocarcinomas: Characteristics and Prognostic Implications Diseases of the Esophagus
  6. A feasibility study to investigate the utility of a home-based exercise intervention during and after neo-adjuvant chemotherapy for oesophago-gastric cancer-the ChemoFit study protocol. Pilot and Feasibility Studies
  7. ASO Author Reflections: Gastric Cancer Staging: More than Just TNM? Annals of Surgical Oncology
  8. ASO Author Reflections: Assessing the Impact of Neoadjuvant Therapy: A Real View Perspective. Annals of Surgical Oncology
  9. Prognostic Significance of Lymphatic, Venous and Perineural Invasion After Neoadjuvant Chemotherapy in Patients with Gastric Adenocarcinoma. Annals of Surgical Oncology
  10. Significance of Neoadjuvant Downstaging in Carcinoma of Esophagus and Gastroesophageal Junction. Annals of Surgical Oncology
  11. Defining true impact of anastomotic leaks after oesophagogastric cancer surgery. British Journal of Surgery
  12. Critical appraisal of the impact of surgical repair of type II-IV paraoesophageal hernia (POH) on pulmonary improvement: A systematic review and meta-analysis. The Surgeon
  13. Trainee performance in radical gastrectomy and its effect on outcomes. British Journal of Surgery Open
  14. ASO Author Reflections: Anastomotic Leaks After Esophagectomy-No Impact on Long-Term Survival. Annals of Surgical Oncology
  15. Anastomotic Leak Does Not Impact on Long-Term Outcomes in Esophageal Cancer Patients. Annals of Surgical Oncology
  16. Long-term outcomes of clinical and pathological-staged T3 N3 esophageal cancer. Diseases of the Esophagus


  1. Pre-operative variables including fitness associated with complications after oesophagectomy. Anaesthesia 
  2. Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK MRC OE05): an open-label, randomised phase 3 trial. Lancet Oncology 
  3. Letter in response to Singh et al: A Randomized Controlled Study to Evaluate the Role of Video-based Coaching in Training Laparoscopic Skills. Annals of Surgery 
  4. ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS). BMC Cancer 
  5. Clinical outcomes and benefits for staging of surgical lymph node mapping after esophagectomy. Diseases of the Esophagus 
  6. Impact of Extent of Lymphadenectomy on Survival, Post Neoadjuvant Chemotherapy and Transthoracic Esophagectomy. Annals of Surgery  
  7. Cancer of the esophagus and esophagogastric junction: an 8th edition staging primer. Journal of Thoracic Diseases 
  8. Systemic inflammatory markers and outcome in patients with locally advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction. British Journal of Surgery 
  9. Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2-3 trial. Lancet Oncology 
  10. Individualised Expert Feedback is Not Essential for Improving Basic Clinical Skills Performance in Novice Learners: A Randomized Trial. Journal of Surgical Education 


  1. Columnar Metaplasia in the Esophageal Remnant After Esophagectomy: A Common Occurrence and a Valuable Insight Into the Development of Barrett Esophagus. Annals of Surgery 
  2. Surgical Proficiency in the Era of Centralization. Journal of Clinical Oncology 
  3. Prognostic Significance of the Location of Lymph Node Metastases in Patients With Adenocarcinoma of the Distal Esophagus or Gastroesophageal Junction. Annals of Surgery 
  4. Prognostic impact of extracapsular lymph node involvement after neoadjuvant therapy and oesophagectomy. British Journal of Surgery 
  5. Recommendations for pathologic staging (pTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Diseases of the Esophagus 
  6. Recommendations for clinical staging (cTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Diseases of the Esophagus 
  7. Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals. Diseases of the Esophagus 
  8. Worldwide Esophageal Cancer Collaboration: clinical staging data. Diseases of the Esophagus 
  9. Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data. Diseases of the Esophagus 
  10. Worldwide Esophageal Cancer Collaboration: pathologic staging data. Diseases of the Esophagus 
  11. The impact of neoadjuvant chemotherapy on cardiopulmonary physical fitness in gastro-oesophageal adenocarcinoma. Annals of the Royal College of Surgeons of England 
  12. Management and outcomes of anastomotic leaks after oesophagectomy. British Journal of Surgery  
  13. What surgeons tell patients and what patients want to know before major cancer surgery: a qualitative study. BMC Cancer 
  14. Fitness after chemotherapy. British Journal of Anaesthesia